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Attending Staff
Dr Sulaiman Nanji

Dr Sulaiman Nanji

University Position:
Assistant Professor

Current Appointments:
Attending Staff, Hotel Dieu Hospital
Attending Staff, Kingston General Hospital

Areas of Clinical Interest:
Liver, Pancreas & Biliary Tract Cancers/Diseases

Areas of Research Interest:
Genetic research in hepatocellular carcinoma and clinical outcomes in hepato-pancreaticobiliary malignancies

Contact Information:
Department of Surgery
Victory 3 Rm 354
Ph (613) 549-6666 x3534
Fax (613) 548-2406

Click here to email Dr Nanji

Fellowship:
• 2007-2009, Clinical Fellow, Multi-Organ Transplantation and Hepatobiliary/Pancreatic Surgery, University of Toronto, Toronto, Ontario

Residency:
• 1999-2007, University of Alberta, Edmonton, Alberta

Medical School Graduation:
• 1995-1999, University of British Columbia, Vancouver, British Columbia

Professional Memberships:
• 2008-present, American Society of Transplant Surgeons
• 2008-present, American Hepato-Pancreato-Biliary Association
• 2004-present, Canadian Society for Clinical Investigation
• 2003-present, Canadian Society for Transplantation
• 2003-present, Canadian Medical Association
• 2002-present, Canadian Association of General Surgeons
• 2001-present, Royal College of Physicians and Surgeons of Canada
• 2003-2006, Aerospace Medical Association

Certifications and Licensure:
• 2007, College of Physicians and Surgeons of Ontario
• 2007, Fellow, Royal College of Physicians and Surgeons of Canada
• 2007, Clinical Investigator, Royal College of Physicians and Surgeons of Canada
• 2002, American College of Surgeons Advanced Trauma Life Support Instructor
• 2001, Licentiate of the Medical Council of Canada (LMCC)

Scholarships and Awards:

Research

2005			University of Alberta, General Surgery Resident Research Day Second Prize Award
2004			Canadian Society for Clinical Investigation Resident Research Prize
2004			Canadian Association of General Surgeons Basic Science Award
2004			University of Alberta, George R Graham Postgraduate Memorial Bursary in Surgery
2004			University of Alberta, Postgraduate Medical Publication Prize
2004			University of Alberta, Department of Surgery Resident Research Second Prize Award
2004			Canadian Society of Transplantation Young Investigator Award
2004			Genzyme Canada Fellows Award for Transplantation
2003			Canadian Association of General Surgeons Basic Science Award
2003			University of Alberta, Department of Surgery Resident Research Day Second Prize Award
2003			University of Alberta, General Surgery Resident Research Day First Prize Award
2002			Canadian Society for Clinical Investigation Poster Competition Award
2002			Canadian Association of General Surgeons Basic Science Award
2002			University of Alberta, General Surgery Resident Research Day Third Prize Award

Academic

2003	University of Alberta, Honorary Sir Izaak Walton Killam Memorial Scholarship
2002-2003	Canadian Association of General Surgeons Research Grant Award
2001-2004	The Canadian Institutes of Health Research Postdoctoral Fellowship Award
2001-2003	The Alberta Heritage Foundation for Medical Research Clinical Fellowship Award
1997	Samuel Diamond UBC Faculty of Medicine Scholarship
1996	Louis Lipsey Toohill UBC Faculty of Medicine Scholarship
1996	Medical Research Council Summer Studentship Award for Surgical Research
1990	Premier's Excellence Award for Community and Scholastic Achievement
1990	Provincial Scholarship Award
1990	Canada Scholarship Award
1990	Aga Khan Award for Scholastic Achievement
1990	Surrey, White Rock Scholarship for Academic Achievement
1990	Sir William Macdonald Entrance Scholarship to McGill University
1990	Royal Canadian Geographical Society Award for Outstanding Research
1990	Gordon M. Shrum Entrance Scholarship to Simon Fraser University for Exceptional Academic Promise

Other

2004	Canadian Space Agency Aerospace Medicine Award
1990	Terry Fox Humanitarian Award
1990	David Welch Memorial Award from the Kiwanis Association for Outstanding Humanitarianism
1990	Josten's Foundation Award for Excellence in Leadership
1988-1994	Duke of Edinburgh's Bronze, Silver and Gold Awards

University/Administrative Services:

2001-present	Medical Student/Resident Teaching, University of Alberta and University of Toronto
2006-2008	Canadian Association of General Surgeons (CAGS) Hepatobiliary Oncology and Transplantation Committee Member
2001-2006	University of Alberta, Faculty of Medicine and Department of Surgery Selection Committee Member
2004-2005	University of Alberta, Department of Surgery Resident Training Committee
2004-2005	University of Alberta, Department of Surgery Research Committee
2001-2005	University of Alberta, Division of General Surgery Journal Club
1996-1999	University of British Columbia Faculty of Medicine Activities
1995-1997	University of British Columbia Health Outreach Peer Education Program (HOPE)
1994-1995	McGill University Health Services Peer Education Program

Research Training and Experience:

2007-present	Liver resection for colorectal cancer metastases Toronto General Hospital, Toronto, ON Supervisor: Dr Steven Gallinger Project: Evaluation of clinical outcomes in hepatic resection for CRC metastases as well as the effect of chemotherapy associated liver injury
April 2004	National Aeronautics and Space Administration (NASA) and Canadian Space Agency (CSA) Aerospace Medicine Elective Johnson Space Center, Houston, Texas Project: Enhance the understanding of medical and surgical challenges during long duration spaceflight (e.g. lunar or Mars missions) with an emphasis on changes in immune function
2001-2004	Tolerance Induction in Experimental Islet Transplantation - PhD Dissertation Supervisor: Dr AM James Shapiro Project: Development of clinically translatable strategies for tolerance induction in patients undergoing islet transplantation
2001-2003	Health Related Quality of Life in Islet Transplantation Department of Public Health Sciences & Institute of Health Economics, Edmonton, Alberta Supervisor: Dr JA Johnson Project: Evaluation of quality of care and clinical effectiveness of islet transplantation through the longitudinal assessment of quality of life in islet transplant patients, as compared to type 1 diabetic patients and pancreas transplant patients
July-Aug 2003	University of Texas Medical Branch Aerospace Medicine Summer Studentship Galveston, Texas & Johnson Space Center, Houston, Texas Supervisor: Dr J Jernigan & Dr R Jennings Project: Understanding alternations in human immune function in space
July-Sept 2002	Visiting Scholar to Emory University Department of Biology and Transplantation Research, Emory University, Atlanta, Georgia Project: Novel approaches to transplantation tolerance involving the induction of mixed chimerism in small and large animal models
1997-1999	Clinical Research in General Surgery Department of Surgery, University of British Columbia, Vancouver, British Columbia Supervisor: Dr DB Allardyce Project: Antibiotics and emergence of Clostridium difficile colitis in surgical patients
1996-1997	Clinical Research in Vascular Surgery Department of Surgery, University of British Columbia, Vancouver, British Columbia Supervisor: Dr RG Turnbull Project: Development of guidelines to define maximum waiting times for definitive surgical treatment of various vascular conditions
June-Aug 1993	Rural Health Care Development in the Northern Areas of Pakistan Aga Khan University and Health Services, Gilgit, Pakistan Supervisor: Dr S Rasmussen Project: Strategies to reduce infant mortality in underdeveloped areas of Northern Pakistan

Grant Support:

Agency	Investigators	Project Title	Period of Support	Amount
National Institutes of Health/NIDDK	Shapiro, AMJ (PI) Anderson, CC (co-PI) Nanji, S (Co-Investigator	ICOS-B7h in Islet Transplant Rejection and Autoimmunity	2003-2005	500,000 US (total)
Lifescan Inc. (Johnson & Johnson)	Shapiro, AMJ (PI) Nanji S (Co-Investigator)	Animal Model for LIving-Donor Islet Transplantation	2004-2005	80,000 Cdn (total)
Canadian Association of General Surgeons	Nanji S (PI)	Costimulatory Blockade and Tolerance Induction in Islet Transplantation	2002-2003	10,000 Cdn (total)
The Canadian Institutes of Health Research	Nanji S	Tolerance Induction in Experimental Islet Transplantation	2001-2004	Salary Stipend
The Alberta Heritage Foundation for Medical Research	Nanji S	Tolerance Induction in Experimental Islet Transplantation	2001-2004	Salary Stipend

Peer-Reviewed Research Presentations:

March 2009	Chemotherapy-Associated Liver Injury in Resections for Metastatic Colorectal Carcinoma: Vascular Injury, but not Steatohepatitis, is Associated with Type of Preoperative Chemotherapy American Hepato-Pancreato-Biliary Association, Miami, Florida, USA
March 2005	Blockade of CD40 is an Effective Strategy in Prolonging Islet Allograft Survival Canadian Society of Transplantation, Banff, Alberta
April 2004	Alterations in Immune Function During Spaceflight Canadian Space Agency, Montreal, Quebec
Oct 2004	Medical and Surgical Challenges in Long Duration Spaceflight Province Wide Rounds, Edmonton, Alberta
Sept 2004 May 2004	Combined Blockade of ICOS and CD40L Costimulation Induces Dominant Tolerance to Islet Allografts and Prevents Spontaneous Autoimmune Diabetes in NOD Mice International Congress of the Transplantation Society, Vienna, Austria Department of Surgery Resident Research Day, Edmonton, Alberta
May 2004 Feb 2004	A Role for Graft Site and Lymphatics in the Effectiveness of Costimulation Blockade-Based Strategies in Murine Models of Transplantation American Transplant Congress, Boston, MA Canadian Society of Transplantation, Montreal, Quebec
Feb 2004	Combination Therapy with CD40L mAb and Rapamycin Induces Robust Immunological Tolerance to Islet Allografts Canadian Society of Transplantation, Montreal, Quebec
Sept, July, June 2003	Multiple Combination Therapies Involving Blockade of ICOS/B7RP-1 Costimulation Facilitate Long-Term Allograft Survival Canadian Surgery Forum, Vancouver, British Columbia International Pancreas and Islet Transplant Association, Dublin, Ireland Department of Surgery Resident Research Day, Edmonton, Alberta
June, Mar and Mar 2003	Targeting the ICOS-B7h Pathway Synergizes with Rapamycin to Regulate Alloresponses in vivo American Transplant Congress, Washington DC International Cell Transplant Society, Atlanta, Georgia The Canadian Society of Transplantation, Lake Louise, Alberta
Sept 2002, Sept 2002 and May 2002	Anti-ICOS Antibody and Sirolimus Leads to Prolonged Islet Allograft Surgival The Canadian Society for Clinical Investigation, Ottawa, ON Canadian Surgery Forum, London, ON Department of Surgery, Resident Research Day, Edmonton, Alberta
April 2002 and Feb 2002	Islet Transplantation and Health-Related Quality of Life American Transplant Congress, Washington, DC Canadian Society of Transplantation, Montreal, Quebec
April 2002	Portal Venous Pressure Changes Following Sequential Islet Transplantation American Transplant Congress, Washington, DC

Peer-Reviewed Publications:

Papers:

1.	Ryan P, Nanji S, Pollett A, Moulton CA, Gallinger S, Guindi M. Chemotherapy-Induced Liver Injury in Metastatic Colorectal Cancer: Semi-Quantitative Histologic Analysis of 334 Resected Liver Specimens Shows Vascular Injury but not Steatohepatitis is Associated with Preoperative Chemotherapy. Journal of Clinical Oncology 2009 (submitted)
2.	Dubay DA, Kachura JR, Ho CS, Beecroft JR, Cheow PC, Vollmer CM, Ghanekar A, Guba M, Nanji S, Cattral MS, McGilvary ID, Kashfi A, Qiu K, Smirth RJ, Sherman M, Levy GA, Grant DR, Greig PD. Is Radiofrequency Ablation of Hepatocellular Carcinoma as a Bridge to Transplant Beneficial? Liver Transplantation 2009 (submitted)
3.	Luo B, Chan WFN, Lord SJ, Nanji S, Rajotte, Shapiro AMJ, Anderson CC. Diabetes Induces Rapid Suppression of Adaptive Immunity Followed by Homeostatic T Cell Proliferation. Scandinavian Journal of Immunology 2007;65(1):22-31
4.	Nanji SA, Hancock WW< Luo B, Schur CD, Pawlick RL, Zhu LF, Anderson CC, Shapiro AMJ, Costimulation Blockade of Both Inducible Costimulator and CD40 Ligand Induces Dominant Tolerance to Islet Allografts and PRevents Spontaneous Autoimmune Diabetes in the NOD Mouse. Diabetes 2006;55(1):27-33
5.	Nanji SA, Shapiro AMJ. Advances in Pancreatic Islet Transplantation in Humans. Diabetes, Obesity & Metabolism 2006;8(1):15-25
6.	Luo B, Nanji SA, Schur CD, Pawlick RL, Anderson CC, Shapiro AMJ, Robust Tolerance to Fully Allogeneic Islet Transplants Achieved by Chimerism with Minimal Conditioning. Transplantation 2005;80(3):370-7
7.	Nanji SA, Shapiro AMJ. Costimulation Blockade in Transplantation. European Journal of Hospital Pharmacy 2004;10(5):28-9
8.	Nanji SA, Shapiro AMJ. Islet Transplantation in Patients with Diabetes Mellitus: Choice of Immunosuppression. Biodrugs 2004;18(5):315-28
9.	Nanji SA, Hancock WW, Anderson CC, Adams AB, Luo B, Schur CD, Pawlick RL, Wong L, Coyle AJ, Larsen CP, Shapiro AMJ. Multiple Combination Therapies Involving Blockade of ICOS/B7RP-1 Costimulation Facilitate Long-Term Islet Allograft Survival. American Journal of Transplantation 2004;4(4):526-536
10.	Nanji SA, Hancock WW, Anderson CC, Zhu LF, Kneteman NM, Shapiro AMJ. Combination Therapy with Anti-ICOS and Cyclosporine Enhances Cardiac but not Islet Allograft Survival. Transplantation Proceedings 2003;35(7):2477-8
11.	Shapiro AMJ, Nanji SA, Lakey JRT. Clinical Islet Transplantation: Current and Future Directions Towards Tolerance. Immunological Reviews 2003;196:219-36
12.	Casey JJ, Lakey JRT, Ryan EA, Paty BW, Owen R, O'Kelly K, Nanji S, Rajotte RV, Korbutt GS, Bigam D, Kneteman NN, Shapiro AMJ. Portal Venous Pressure Changes Following Sequential Islet Transplantation. Transplantation 2002;74(7):913-15
13.	Turnbull RG, Taylor DC, Hsiang YN, Salvian AJ, Nanji SA, O'Hanley G, Doyle DL, Fry PD. Assessment of Patient Waiting Times for Vascular Surgery. Canadian Journal of Surgery 2000;43(2):105-11
14.	Nanji SA, Mock CN, Gastric Rupture Resulting from Blunt Abdominal Trauma and Requiring Gastric Resection. Journal of Trauma 1999;47(2):410-12

Abstracts:

1.	Ryan P, Nanji SA, Pollett A, Moore M, Moulton CA, Guindi M, Gallinger S. Use of Oxaliplatin and Irinotecan Prior to Hepatic Resection of Colorectal Cancer Metastases is not Associated with Chemotherapy-Associated Steatohepatitis (CASH) in a Clinic-Based Canadian Population. HPB 2009;11(S1):39
2.	Nanji SA, Anderson CC, Luo B, Hancock WW, Adams AB, Schur CD, Pawlick RL, Zhu LF, Kneteman NM, Shapiro AMJ. A Role for Graft Site and Lymphatics in the Effectiveness of Costimulation Blockade-Based Strategies in Murine Models of Transplantation. American Journal of Transplantation 2004;4(S8):510
3.	Nanji SA, Hancock WW, Anderson CC, Adams AB, Luo B, Schur CD, Pawlick RL, Wong L, Coyle AJ, Larsen CP, Shapiro AMJ. Targeting the ICOS-B7h Costimulatory Pathway Synergizes with Rapamycin to Regulate Alloresponses in Islet Transplantation. Cell Transplantation 2003;12(2)
4.	Nanji SA, Hancock WW, Anderson CC, Adams AB, Luo B, Schur CD, Pawlick RL, Wong L, Coyle AJ, Larsen CP, Shapiro AMJ. Targeting the ICOS-B7h Costimulatory Pathway Synergizes with Rapamycin to Regulate Alloresponses in Islet Transplantation. Transplantation 2003;76(4 Suppl):S19-68
5.	Nanji SA, Hancock WW, Anderson CC, Adams AB, Luo B, Schur CD, Pawlick RL, Wong L, Coyle AJ, Larsen CP, Shapiro AMJ. Targeting the ICOS-B7h Costimulatory Pathway Synergizes with Rapamycin to Regulate Alloresponses in Islet Transplantation. American Journal of Transplantation 2003;S5(3):291
6.	Casey JJ, Lakey JRT, Ryan EA, Paty BW, Owen R, O'Kelly K, Nanji S, et al. Portal Venous Pressure Changes Following Sequential Islet Transplantation. American Journal of Transplantation 2002;S3(2):228
7.	Johnson JA, Nanji SA, Supina A, LAkey, JRT, Ryan EA, Shapiro AMJ, Islet Transplantation and Health-Related Quality of Life: Results of an Initial Pilot Study. American Journal of Transplantation 2002;S3(2):229

Book Chapters:

1.	Shapiro AMJ, Nanji SA. Progress in Islet Transplantation. Book Chapter in Stem Cells: From Bench to Bedside. Edited by Ariff Bongso and Eng Hin Lee. World Scientific Publishing 2005.