Evidence-Based Medicine

"Evidence-Based Medicine (EBM) is the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients." David Sackett (1996)

Introduction

• What is EBM?
(Centre for EBM, Toronto)
• What it is and what it isn't
(David Sackett)

Centres and Institutes

• Campbell Collaboration
(social and educational policies)
• Canadian Cochrane Centre (University of Ottawa)
• Canadian Coordinating Office for Health Technology Assessment (CCOHTA)
• Centre for Evidence-Based Medicine (Mount Sinai Hospital, Toronto)
• Centre for Evidence-Based Medicine (Oxford, UK)
• Centre for Health Evidence (University of Alberta)
• Cochrane Collaboration (International)
• Cochrane Site Group (Queen's University)
• Evidence-based Practice Centers (United States and Canada)
• McMaster University
• University of Alberta
• University of Ottawa
• Institute of Population Health (University of Ottawa)
• National Center for Complementary and Alternative Medicine (NIH)

Critical Appraisal

• Baseline data (EBM: Trials on Trial)
• Book list (Biostatistics and Epidemiology)
• CanMEDS 2000 (Scholar Role)
• Criteria for causation (Sir Bradford Hill)
• Critical appraisal checklists (CASP)
• How to pick the correct statistic (Phil Hahn)
• Intention-to-treat principle (EBM: Trials on Trial)
• Key concepts (Epidemiology and Biostatistics)
• Levels of evidence (Centre for Evidence-Based Medicine, Oxford)
• Making sense of odds (David Grimes 2008)
• Noninferiority trials (Stuart Pocock 2003)
• Reporting statistical information (Peter Cummings 2003)
• Soundbites: Key concepts in clinical research (Phil Hahn)
• Subgroup analysis (Cook 2004)
• Tips for an effective Journal Club (Phil Hahn)
• Users' guides to the Medical Literature (JAMAevidence)
• What's wrong with Bonferonni adjustments? (Thomas Perneger 1998)

Reporting Guides

• CONSORT (randomized trials)
• CONSORT extension (cluster trials)
• CONSORT extension (noninferiority and equivalence trials)
• MOOSE (meta-analysis of observational studies)
• QUORUM (meta-analysis of RCTs)
• PRISMA (systematic reviews and meta-analyses)
• STARD (diagnostic tests)
• STROBE (observational studies)
• TREND (nonrandomized evaluations)

Critical Reviews of Health News

• Behind the Headlines (UK)
• Health News Review (US)
• Healthy Skepticism (Washington Post)
• Hitting the Headlines: Archive (UK)
• Media Doctor (Australia)
• Media Doctor (Canada)

Glossaries

• EBM (Bandolier)
• EBM (Centre for Evidence-Based Medicine, Toronto)

Resources

• ACP Journal Club
• Bandolier
• Chris Cates' EBM Web Site (NNT graphical display)
• Clinical Evidence
• ClinicalTrials.gov (NIH Clinical Trials Registry)
• Cochrane Library
• EBM Online (For Primary Care and Internal Medicine)
• Essential Evidence PLUS
(Wiley-Blackwell)
• Evidence-Based On-call (EBOC)
• Evidence-Based Practice Resources (Bracken Library)
• Evidence Updates
(BMJ Evidence Centre)
• Health Sciences Resources for Handheld Computers (Bracken Library)
• Natural Standard (Complementary and alternative therapies) (Bracken Library)
• Physiotherapy Evidence Database
(PEDro)
• PubMed (National Library of Medicine)
• Translating Research Into Practice (TRIP Database)
• UpToDate

What is...series? (Hayward Medical Communications)

• What is critical appraisal?
• What is evidence-based medicine?
• What makes a good clinical guideline?
• What are confidence intervals?
• What is a Cox model?
• What is a number-needed-to-treat (NNT)?
• Implementing NNTs
• What is meta-analysis?
• What is quality of life?
• What is a quality-adjusted life-year (QALY)?
• Implementing QALYs
• What is a systematic review?

What is...? (source)

• What is an odds ratio? (Jon Deeks for Bandolier)
• What is a P value? (GraphPad.com)
• What is person-time? (ERIC Notebook)
• What is a survey? (Fritz Scheuren)

Updated: April 26, 2011 (P.Hahn)