Dr. David Reed
M.D., Ph.D.
Asst. Professor, Dept. of Medicine

Office Tel: 613 549-6666 ext. 6524
Lab Tel: 613 549-6666 ext. 6531
email: david.reed@queensu.ca

to the
Reed Lab

Our lab is interested in the role of nutrient sensing in the distal gut and its role in functional gastrointestinal disorders such as irritable bowel syndrome. More specifically, we are interested in how nutrient factors activate extrinsic afferent nerves innervating the distal gut as well as how these factors modulate mechanical activation of sensory nerves. We then examine how these pathways may be altered under conditions associated with irritable bowel syndrome (e.g. stress, post-infection).

Techniques we use include extracellular recordings to record from extrinsic sensory nerves, mucosal release assays of mediators released by nutrient stimulation, and immunohistochemistry. We will also use these techniques to examine nutrient signalling mechanisms in human tissue obtained following surgical resection or endoscopic biopsy.