BLENNERHASSETT LAB

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Last updated: September 16, 2016
 
 

Dr. Michael Blennerhassett
GIDRU, Kingston General Hospital
blennerm@queensu.ca

 

 

Latest publications! 2015

Intestinal smooth muscle phenotype determines enteric neuronal survival via GDNF expression. Han TY, Lourenssen S, Miller KG, Blennerhassett MG. Neuroscience. 2015 Feb 2. pii: S0306-4522(15)00113-X. doi: 10.1016/j.neuroscience.2015.01.056.

Early inflammatory damage to intestinal neurons occurs via inducible nitric oxide synthase. Venkataramana S, Lourenssen S, Miller KG, Blennerhassett MG. Neurobiol Dis. 2015 Jan 3;75C:40-52. doi: 10.1016/j.nbd.2014.12.014.

 

 

 
 

Welcome to the Blennerhassett Lab

We examine the effects of inflammation on the nerve-smooth muscle relationship of the intestine. Using immunocytochemistry, morphometric analysis and functional assays, we study the structure and function of intestinal innervation, as well as smooth muscle cell physiology.

While establishing a better knowledge of physiology then allows investigation of the changes seen in the inflamed intestine, little is known in this area and the studies of normal and inflamed tissue commonly proceed in parallel. Our recent work has shown that transmural inflamation of the rat colon causes irreversible loss of myenteric and submucosal neurons. Further, we found that rapid and extensive axonal proliferation by the surviving neurons re-innervates the smooth muscle cells. This may be directly applicable to our understanding of human disease, since neuronal loss and damage could lead to the symptoms of post-enteritis Irritable Bowel Syndrome (IBS).

 

More publications

Intestinal smooth muscle phenotype determines enteric neuronal survival via GDNF expression. Han TY, Lourenssen S, Miller KG, Blennerhassett MG. Neuroscience. 2015 Feb 2. pii: S0306-4522(15)00113-X. doi: 10.1016/j.neuroscience.2015.01.056. [Epub ahead of print]

Early inflammatory damage to intestinal neurons occurs via inducible nitric oxide synthase. Venkataramana S, Lourenssen S, Miller KG, Blennerhassett MG. Neurobiol Dis. 2015 Jan 3;75C:40-52. doi: 10.1016/j.nbd.2014.12.014. [Epub ahead of print]

Inflammatory cytokines promote growth of intestinal smooth muscle cells by induced expression of PDGF-Rβ Nair DG, Miller KG, Lourenssen SR, Blennerhassett MG. J Cell Mol Med. 2014 Mar;18(3):444-54.

Impaired platelet-derived growth factor receptor expression and function in cultured lower esophageal sphincter circular smooth muscle cells from W/W(v) mutant mice. Bautista-Cruz F, Nair DG, Lourenssen S, Miller DV, Blennerhassett MG, Paterson WG . Can J Physiol Pharmacol. 2014 Jan;92(1):34-41. 

The pro-inflammatory cytokines IL-1β and TNFα are neurotrophic for enteric neurons. Gougeon PY, Lourenssen S, Han TY, Nair DG, Ropeleski MJ, Blennerhassett MG. J Neurosci. 2013 Feb 20;33(8):3339-51. doi: 10.1523/JNEUROSCI.3564-12.2013.

Proliferation modulates intestinal smooth muscle phenotype in vitro and in colitis in vivo. Nair DG, Han TY, Lourenssen S, Blennerhassett MG. Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G903-13. doi: 10.1152/ajpgi.00528.2010. Epub 2011 Feb 10.

 

 

 

 

 

 

       

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