Pain Management

Ongoing Studies:

Shyam, V, Wilson, R.: Patient controlled epidural anesthesia (PCEA) versus continuous epidural anesthesia (CEA) for Open Thoracotomy: Optimal dosing ratios

VanDenKerkhof, E.: Monitoring chronic pain after abdominal surgery: questionnaire study

Wilson, R.: Pre-Knee Teaching study looking at post-operative pain outcomes

Recently completed studies:

Lee A, Ramsey G, Orr E, Murdoch J. The effects of intraperitoneal ketorolac on postoperative pain following laparoscopic cholecystectomy

Abstract

Sydor D, Engen D, VanDenKerkhof EG, Orr E, Dumerton-Shore, D., Jaeger M. A randomized controlled trial comparing two doses of spinal bupivacaine for total knee arthroplasty and the impact on recovery time Abstract

Zamora, J, Turner, K and D Dumerton-Shore - Perioperative Pregabalin for the prevention of post-thoracotomy pain syndrome: A pilot study

Starting soon:

A randomized controlled trial of combination pharmacotherapy for postsurgical pain and functional recovery: Click here to see protocol

Zamora, J, Turner, K and Dumerton-Shore, D: Peri-operative Pregabalin for the prevention of post-thoracotomy pain syndrome: multi-centre study (Click here to see protocol)

Most Recent Publications:

Boscariol R, Gilron I, Orr E. (2007) Chronobiological characteristics of postoperative pain: diurnal variation of both static and dynamic pain and effects of analgesic therapy. Can J Anaesth. 54(9):696-704.

Cahill CM, Holdridge SV, Morinville A. (2007) Trafficking of delta-opioid receptors and other G-protein-coupled receptors: implications for pain and analgesia. Trends Pharmacol Sci.;28(1):23-31

Deshpande MA, Holden RR, Gilron I (2006) The impact of therapy on quality of life and mood in neuropathic pain: what is the effect of pain reduction? Anesth Analg. 102(5):1473-9.

Erb J, Orr E, Mercer CD, Gilron I. (2008) Interactions between pulmonary performance and movement-evoked pain in the immediate postsurgical period: implications for perioperative research and treatment Reg Anesth Pain Med. 2008 Jul-Aug;33(4):312-9.

Gilron I. (2006) Review article: the role of anticonvulsant drugs in postoperative pain management: a bench-to-bedside perspective. Can J Anaesth. 53(6):562-71-Review

Gilron I. (2007) Gabapentin and pregabalin for chronic neuropathic and early postsurgical pain: current evidence and future directions. Curr Opin Anaesthesiol. (5):456-72. Review

Gilron I, Orr E, Tu D, Mercer CD, Bond D (2009) A randomized, double-blind, controlled trial of perioperative administration of gabapentin, meloxicam and their combination for spontaneous and movement-evoked pain after ambulatory laparoscopic cholecystectomy Anesth Analg. 108(2):623-30.

Gilron I, Watson CP, Cahill CM, Moulin DE. (2006) Neuropathic pain: a practical guide for the clinician.

CMAJ. 175(3):265-75. Review.

Holdridge SV, Armstrong SA, Taylor AM, Cahill CM. (2007) Behavioural and morphological evidence for the involvement of glial cell activation in delta opioid receptor function: implications for the development of opioid tolerance. Mol. Pain. 2007 Mar 12;3:7

Holdridge SV, Cahill CM. (2007) Spinal administration of a delta opioid receptor agonist attenuates hyperalgesia and allodynia in a rat model of neuropathic pain. Eur J Pain. 2007 Aug;11(6):685-93.

Jhamandas K, Milne B, Sutak M, Gouarderes C, Zajac JM, Yang HY. (2006) Facilitation of spinal morphine analgesia in normal and morphine tolerant animals by neuropeptide SF and related peptides.

Peptides. 27(5):953-63

Kabli N, Cahill CM. (2007) Anti-allodynic effects of peripheral delta opioid receptors in neuropathic pain.

Pain. 127(1-2):84-93.

Messenger DW, Murray HE, Dungey PE, van Vlymen J, Sivilotti ML (2008) Subdissociative-dose ketamine versus fentanyl for analgesia during propofol procedural sedation: a randomized clinical trial. Acad Emerg Med. 15(10):877-86.

Milne B, Sutak M, Cahill CM, Jhamandas K. (2008) Low doses of alpha 2-adrenoceptor antagonists augment spinal morphine analgesia and inhibit development of acute and chronic tolerance. Br J Pharmacol. 2008 155(8):1264-78.

Morano TJ, Bailey NJ, Cahill CM, Dumont EC (2007) Nuclei-and condition-specific responses to pain in the bed nucleus of the stria terminalis. Prog Neuropsychopharmacol Biol Psychiatry. 32(3):643-50

Odrcich M, Bailey JM, Cahill CM, Gilron I. (2006) Chronobiological characteristics of painful diabetic neuropathy and postherpetic neuralgia: diurnal pain variation and effects of analgesic therapy.

Pain. 120(1-2):207-12.

Tripp DA, Nickel JC, Wang Y, Litwin MS, McNaughton-Collins M, Landis JR, Alexander RB, Schaeffer AJ, O'Leary MP, Pontari MA, Fowler JE Jr, Nyberg LM, Kusek JW; (2006) Catastrophizing and pain-contingent rest predict patient adjustment in men with chronic prostatitis/chronic pelvic pain syndrome. National Institutes of Health-Chronic Prostatitis Collaborative Research Network (NIH-CPCRN) Study Group. J Pain. 7(10):697-708.

VanDenKerkhof EG, Hopman WM, Towheed T, Wilson R, Murdoch J, Rimmer M, Stutzman SS, Tod D, Dagnone V, Goldstein DH. (2006) Pain, health-related quality of life and health care utilization after inpatient surgery: a pilot study. Pain Res Manag. 11(1):41-7.